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The most common side effects of Cialis are headache, flushing, indigestion, and nasal congestion. These side effects are usually mild and temporary. However, if you experience more serious side effects, such as chest pain, changes in heart rate, or changes in blood pressure, contact a doctor immediately. Talk to your doctor if you experience severe or persistent side effects. Cialis may cause serious side effects, such as chest pain, irregular heartbeat, or changes in blood pressure.

Uses of Cialis

Cialis is used for the treatment of erectile dysfunction (ED) in adult men (aged 18 years and older). It is also used to treat benign prostatic hyperplasia (BPH) by relaxing the prostate muscles.

How to Use Cialis

Take one pill about 1 hour before sexual activity. Do not take more than 1 pill in a 24-hour period.

Possible Side Effects

Headache: headache, flushing, indigestion, and nausea or heart attack or stroke. However, if you experience serious side effects or have any concerns, contact a doctor immediately.

Flushing:flushing can be a sign of an allergic reaction, and once it occurs, it is usually mild to moderate in severity.

Headache can be a sign of an enlarged prostate, and if you experience it while having sex, talk to a doctor.

Indigestion:difficulty in sleeping, or people taking nitrates. However, if you have indigestion, contact a doctor immediately.

Nasal Congestion:trouble breathing, like difficulty in breathing or swallowing, and/or nasal congestion can occur.

Back or Muscle Pain:tendon damage, or any inflammation of the tendon, and/or sprains can cause a back or muscle pain, especially in the hands or wrists.

Vision Problems:can occur due to an overactive or hypersensitive immune system, and people with cancer, prostate, or diabetes may develop symptoms such as an exaggerated sense of taste, difficulty in seeing, blurred vision, and/or difficulty in both vision and hearing.

Contact a doctor or health care provider right away if you experience serious side effects such as chest pain, irregular heartbeat, or changes in blood pressure. A doctor should be able to diagnose the side effects and help you determine if Cialis is the right treatment for you.

  • Do not take more than one pill in a 24-hour period.
  • Take Cialis about 1 hour before sexual activity.
  • Take Cialis with a full glass of water.
  • Avoid drinking alcohol while taking Cialis, as it may decrease its effectiveness.

Most side effects are mild and temporary, but others can occur. If you experience serious side effects or have any concerns, talk to a doctor immediately.

How to Take Cialis

The recommended dose of Cialis for adults is 5 mg taken as needed, about 1 hour before sexual activity. The recommended dose is 10 mg, taken approximately 1 hour before sexual activity. Do not take Cialis more than once a day.

Possible Drug Interactions

Nitrates:use in combination with nitrates (used for chest pain, heart problems, or high blood pressure).

Alpha-blockers:used to treat high blood pressure or prostate problems. Do not use Cialis if you have an enlarged prostate, or if you have a heart problem. People using nitrates or alpha-blockers should not take Cialis.

Doxycycline:can be used with Cialis to prevent bacterial infections and to treat acne.

Other Interactions:are not recommended in all cases.

Cialis Usage and Results

Most people using Cialis do not experience side effects or any problems.

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Erectile dysfunction is a common condition that requires urgent care and treatment. This condition, which isrowded nerves, including those for the user, leading to difficulty achieving and maintaining an erection, are damage that allows the penis to sustain its erect state. When there is difficulty in reaching an erection, the user is left with no sexual partner and a feeling of inhibition from the partner.

Erectile dysfunction can occur in any age and typically affects men 30 years or older. The cause is often unknown, but with the introduction of prescription Erectile Dysfunction medicines, the condition is believed to be a major cause of ED user's experience.

There are that can cause sexual dysfunction attributed to hormonal imbalances, cardiovascular disorders, treatments for ED that negatively impact the user, and prescription medications. The most common medications that can negatively impact the user are:- Sildenafil (Viagra) - Tadalafil (Cialis) - Cialis (tadalafil) - Cialis (tadalafil) - Sildenafil (Viagra) - Tadalafil (Cialis) - Tadalafil (Cialis) - Cialis (tadalafil) - Tadalafil (Cialis) - Tadalafil (tadalafil) - Cialis (tadalafil) - Phentolamine (Nexium) - Vardenafil (Levitra) - Viagra

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How does Erectile Dysfunction occur in men? What prescription drugs are available for ED?

Erectile dysfunction occurs if you experience occasional or no erections in the penis during sexual activity. It can be found with different types of drugs such as sildenafil, tadalafil, and Cialis. These drugs have vasodilators that encourage blood flow in the penis, while phosphodiesterase type 5 (PDE5) inhibitors such as Cialis and Viagra impact the blood vessels that supply the penis with blood. This allows the user to achieve and maintain an erection when sexually stimulated.

Erectile dysfunction can occur even if you are not experiencing any episodes of erectile dysfunction. Underlying medical conditions may lead to sexual dysfunction and difficulty with sexual activity. Approval is usually granted by the U. S. Food and Drug Administration (FDA).

For information about how to ask about Erectile Dysfunction, talk to your health care provider.

Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
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Abstract

Background

Phosphodiesterase-5 (PDE-5) inhibitors, such as tadalafil (Cialis) and vardenafil (Levitra), are widely used for treatment of erectile dysfunction. However, there has been a small but significant decrease in PDE-5-isomers’ free radical activity. In particular, the increase of free radical production due to the use of PDE-5 inhibitors is related to the inhibition of PDE-5 and PDE-5 inhibitors.

Objectives

To determine whether the decrease in free radical production due to the use of PDE-5 inhibitors is due to the inhibition of PDE-5. The subjects were randomized to treatment with either tadalafil (Cialis) or vardenafil (Levitra) for 4 weeks. The free radical production was evaluated in each group as well as in each of the other four groups.

Methods

This is a single-center, randomized, double-blind, placebo-controlled trial, that was performed in the Faculty of Pharmacy at the University of Lille. The study was conducted in accordance with the Declaration of Helsinki, and was approved by the Research Ethics Committee of the Faculty of Pharmacy at the University of Lille (No. 3/2022). The study was conducted in accordance with the Declaration of Helsinki, and was registered at ClinicalTrials.gov under registration number NCT0258872. In all patients, informed consent was obtained.

Patients were randomly allocated to treatment groups using a computer-generated allocation sequence. The first month was the first week of treatment. The first two weeks of treatment were followed by a 4-week trial in which a total of 16 patients with erectile dysfunction (ED) and no ED were included. The last three doses were followed by a 4-week trial in which a total of 24 patients were randomized to vardenafil (n=16), tadalafil (n=16), or placebo (n=16) for 4 weeks. At the end of the 4-week trial, the patients were evaluated in terms of the mean corpus cavernosum cavernosum scores and the mean number of erections. All patients were evaluated in terms of the mean corpus cavernosum cavernosum scores, and the mean number of erections, as well as the mean corpus cavernosum cavernosum cavernosum cavernosum cavernosum cavernosum. The patients were classified as patients who had a normal erection during the 4-week trial, and those who had a normal erection during the 4-week trial were classified as patients who had a significant increase in free radical production of the corpus cavernosum (in the range of 0.05-0.10 times).

Results

From the baseline data, there were no significant differences in the mean corpus cavernosum cavernosum cavernosum scores between the treatments, which is consistent with the results of a recent report [].